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Vita-melatonin – instructions, indications and contraindications
Complete instructions for the preparation of Vita-melatonin. Vita-melatonin – instructions, indications and contraindications. Composition and side effects of Vita-melatonin
Trade name: Vita-melatonin About the drug: The total effect of the drug leads to an increase in mental and physical performance, biological changes in sleep and wakefulness, normalization of circadian rhythms, rhythm of gonadotropic effects and sexual function, reduction of stress reactions.
Indications and dosage: Indications for use:
The drug is used for the treatment of sleep disorders, elimination of stress reactions and depressive states of a seasonal nature, prevention and treatment of circadian rhythm disorders (as a result of rapid movement between time zones), increased body fatigue (including chronic insomnia of functional origin, insomnia in the elderly), to increase mental and physical performance.
Mode of application:
The dose of the drug is set by the doctor in each case individually. The drug Vita-melatonin is taken orally by an adult, 1-2 tablets per day half an hour before bedtime. Take daily at the same time. Duration of therapy depends on the elimination of symptoms of disorders. For the purpose of prevention, the drug is prescribed for two months, with a seven-day break between the courses of therapy.
Overdose: Vita-melatonin overdose has been described (single dose 24-30 mg). Excessive consumption can cause loss of memory in previous events, a sense of disorientation, prolonged sleep. Symptomatic treatment. Side effects: Possible morning sleepiness in the early stages of treatment, headache, skin rashes, digestive disorders. Contraindications: Individual sensitivity to the components of the drug, Hodgkin’s disease, autoimmune diseases, lymphoma, leukemia, epilepsy, myeloma, pregnancy, lactation and diabetes . Simultaneous treatment with SCS inhibitors, cyclosporine, monoamine oxidase. The drug is contraindicated for use in children and adolescents. Interaction with other drugs and alcohol:
Drugs such as β-adrenoreceptor blockers, fluvoxamine, dexamethasone, clonidine, and some others can alter the secretion of endogenous melatonin.
The drug Vita-melatonin may reduce the effectiveness of hormonal drugs (androgens, estrogens, etc.), increase the degree of binding of benzodiazepines with specific receptors. The simultaneous appointment of the drug Vita-melatonin with the above means requires the control of the attending physician.
Vita-melatonin may increase the anticarcinogenic effect of tamoxifen.
Serotonergic and dopaminergic effects of methamphetamine can be potentiated by combining them with Vita-melatonin. The active substance of the drug can enhance the antimicrobial action of isoniazid.
Structure and properties: Active ingredient: melatonin. 1 tablet contains melatonin 0.003 g; excipients: calcium stearate, microcrystalline cellulose, milk sugar, potato starch. Release form: tablets.
Pharmacological action: hypnotic drugs and sedatives.
The drug Vita-melatonin is a synthetic analogue of the hormone melatonin, which is synthesized by the epiphysis. The main effect of this drug is to inhibit the secretion of gonadotropins. The drug Vita melatonin inhibits the production of other hormones: adenohypophysis-corticotropin, somatotropin, thyrotropin. Serotonin and GABA levels increase in the midbrain and hypothalamus. The total effect of the drug leads to an increase in mental and physical performance, biological changes in sleep and wakefulness, normalization of circadian rhythms, rhythm of gonadotropic effects and sexual function, and a decrease in the manifestation of stress reactions.
The drug Vita-melatonin stabilizes the cell membrane due to its antioxidant effect. Also, the drug normalizes the permeability of the vascular wall, improves microcirculation, increases resistance to damaging factors. Due to the stimulation of cellular immunity, the drug Vita-melatonin has
It is administered orally. The active substance is metabolized during the initial passage through the liver. Bioavailability of the drug is 30-50%. After taking a dose of 3 mg Cmax (maximum concentration) in the serum is reached on the 20th and 60th minutes. Vita-melatonin passes through the placental blood-brain barriers. The average half-life is 45 minutes. Excreted in the urine.